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AI models for faster drug development

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  18. 18AA
  19. 19GC

    I've built an app that extracts interpretable 'circuits' from models using the GPT-2 architecture. These circuits reveal how specific inputs influence the probabilities of the next token in a sequence. While some tutorials present theoretical examples of how feedforward layers and attention heads may produce predictions, this app provides concrete examples of how information flows through an LLM. You can see, for example, the formation of features that search for simple grammatical patterns and trace their construction back to the use of more primitive features. Feel free to reach out with…

    2024 · peterlai.github.io

  20. 20AP

    Hello Hacker News, I’m releasing TXT Blah Blah Blah Lite, an open-source plain-text AI reasoning engine powered by semantic embedding rotation. It generates 50 coherent, self-consistent answers within 60 seconds — no training, no external APIs, and zero network calls. Why this matters Six top AI models (ChatGPT, Grok, DeepSeek, Gemini, Perplexity, Kimi) independently gave it perfect 100/100 ratings. For context: Grok scores LangChain around 90 MemoryGPT scores about 92 Typical open-source LLM frameworks score 80-90 Key features Lightweight and portable: runs fully offline as a single…

    2025 · github.com

  21. 21NL

    Refuel LLM (84.2%) outperforms trained human annotators (80.4%), GPT-3-5-turbo (81.3%), PaLM-2 (82.3%) and Claude (79.3%) across a benchmark of 15 text labeling datasets. It is a Llama-v2-13b base model, trained on over 2500 unique datasets (5.24B tokens) spanning categories such as classification, entity resolution, matching, reading comprehension and information extraction. Here is the interactive demo: https://labs.refuel.ai/playground. Pretty fun to play with!

    2023

  22. 22AL

    Try it out here: https://labs.refuel.ai/playground Refuel LLM (84.2%) outperforms trained human annotators (80.4%), GPT-3-5-turbo (81.3%), PaLM-2 (82.3%) and Claude (79.3%) across a benchmark of 15 text labeling datasets. It is a Llama-v2-13b base model, trained on over 2500 unique datasets (5.24B tokens) spanning categories such as classification, entity resolution, matching, reading comprehension and information extraction.

    2023

  23. 23

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  24. 24MM

    Hi HN! We (Thomas and Stéphan, hello!) recently released Model2Vec, a Python library for distilling any sentence transformer into a small set of static embeddings. This makes inference with such a model up to 500x faster, and reduces model size by a factor of 15 (7.5M params or 15/30MB on disk, depending on whether you use float16 or float32). This allows you to embed 50-100k documents per second on a cpu on a macbook. This reduction of course comes at a cost: distilled models are worse than their parent models. Even so, they are actually a lot better than large sets of conventional…

    2024 · github.com

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