AI · alternatives · 2026
24 alternatives to TxGemma
AI models for faster drug development
Below are 24 products that do a similar job, ranked by how close each is in meaning and then by launch-day votes. Prices are shown for the 1 we have checked on their own sites, 1 of them free or with a free tier.
- 1
Gemma 2▲279Lightweight, state-of-the-art open models from Google
2024 · blog.google · its alternatives →
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TranslateGemma ▲275Open translation on Google models, supporting 55 languages
Jan 2026 · blog.google · its alternatives →
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Google Gemma 4▲437Google's most intelligent open models to date
Apr 2026 · blog.google · its alternatives →
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GPT-4▲1,160More accurate, less cringe, smoother & useful daily chats!
2023 · openai.com · its alternatives →
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Kitten TTS is an open-source series of tiny and expressive text-to-speech models for on-device applications. We are excited to launch a preview of our smallest model, which is less than 25 MB. This model has 15M parameters. This release supports English text-to-speech applications in eight voices: four male and four female. The model is quantized to int8 + fp16, and it uses onnx for runtime. The model is designed to run literally anywhere eg. raspberry pi, low-end smartphones, wearables, browsers etc. No GPU required! We're releasing this to give early users a sense of the latency and voices…
2025 · github.com · its alternatives →
- 7
Hey HN, Henry from Cactus here! We previously released Cactus Needle, a 14MB agentic LLM for tool call, device use, and structured extraction for phones, wearables, smart homes, small robots and microcontrollers. We got really great feedback here, and have now incorporated the suggestions to release Needle 2. The whole model is a single 14MB binary that runs a full session in 28MB of RAM; 45m parameters at 2bit compression. Needle hits 500 tokens/sec decode speed on a Raspberry Pi 5, sits between 400-1,500 tokens/sec on VR devices like Meta Quest 3S and Apple Vision Pro, and ranges…
Aug 2026 · cactuscompute.com · its alternatives →
- 8
Announcing GPT-4.1, GPT-4.1 mini, & GPT-4.1 nano in the API
2025 · openai.com · its alternatives →
- 9
Hey HN, Henry & Roman here from Cactus. A small, on-device model is fast and private, but sometimes wrong, but frontier models are getting expensive pretty fast. So, we post-trained Gemma 4 E2B post-trained to know when it's wrong. Every response comes with a confidence score between 0 and 1. Developers can accept the on-device when it's high, hand off to a bigger cloud model when it's low. By routing only 15-35% of queries to Gemini 3.1 Flash-Lite, Gemma-4-E2B matches Gemini 3.1 Flash-Lite on most benchmarks. - ChartQA: 15-20% - LibriSpeech: 25-30% - MMBench, GigaSpeech, MMAU: 30-35% -…
Jul 2026 · github.com · its alternatives →
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Google EmbeddingGemma 2free▲318An open, lightweight multimodal embedding model
15d ago · blog.google · its alternatives →
- 11
MARS5 TTS▲489Open-source, insanely prosodic text-to-speech model
2024 · github.com · its alternatives →
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Hi HN - we’re the founders of Ligo Biosciences and are excited to share an open-source implementation of AlphaFold3, the frontier model for protein structure prediction. Google DeepMind and their new startup Isomorphic Labs, are expanding into drug discovery. They developed AlphaFold3 as their model to accelerate drug discovery and create demand from big pharma. They already signed Novartis and Eli Lilly for $3 billion - Google’s becoming a pharma company! (https://www.isomorphiclabs.com/articles/isomorphic-labs-kick...) AlphaFold3 is a biomolecular structure prediction…
2024 · github.com · its alternatives →
- 14
Fast and efficient models optimized for coding and subagents
Mar 2026 · openai.com · its alternatives →
- 15
We release Steerling-8B, an 8B-parameter causal diffusion language model that is interpretable by construction — its predictions are routed through concepts you can measure, audit, and control.
Feb 2026 · guidelabs.ai · its alternatives →
- 16
Gemma Gem is a Chrome extension that loads Google's Gemma 4 (2B) through WebGPU in an offscreen document and gives it tools to interact with any webpage: read content, take screenshots, click elements, type text, scroll, and run JavaScript. You get a small chat overlay on every page. Ask it about the page and it (usually) figures out which tools to call. It has a thinking mode that shows chain-of-thought reasoning as it works. It's a 2B model in a browser. It works for simple page questions and running JavaScript, but multi-step tool chains are unreliable and it sometimes ignores its tools…
Apr 2026 · github.com · its alternatives →
- 17
First TTS model to support all 22 Indic languages + English
2024 · its alternatives →
- 18
ChatLLaMA is an experimental chatbot interface for interacting with variants of Facebook's LLaMA. Currently, we support the 7 billion parameter variant that was fine-tuned on the Alpaca dataset. This early versions isn't as conversational as we'd like, but over the next week or so, we're planning on adding support for the 30 billion parameter variant, another variant fine-tuned on LAION's OpenAssistant dataset and more as we explore what this model is capable of. If you want deploy your own instance is the model powering the chatbot and build something similar we've open sourced the Truss…
2023 · chatllama.baseten.co · its alternatives →
- 19
Open source data labelling platform for AI model tuning
2023 · labelstud.io · its alternatives →
- 20
Zoo▲234A free, open-source playground for AI image models
2023 · zoo.replicate.dev · its alternatives →
- 21
Hi, I’m Jakub, a solo founder based in Warsaw. I’ve been building GoModel since December with a couple of contributors. It's an open-source AI gateway that sits between your app and model providers like OpenAI, Anthropic or others. I built it for my startup to solve a few problems: - track AI usage and cost per client or team - switch models without changing app code - debug request flows more easily - reduce AI spendings with exact and semantic caching How is it different? - ~17MB docker image - LiteLLM's image is more than 44x bigger ("docker.litellm.ai/berriai/litellm:latest" ~…
Apr 2026 · github.com · its alternatives →
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Ollama for classical ML models. AOT compiler that turns XGBoost, LightGBM, scikit-learn, CatBoost & ONNX models into native C99 inference code. One command to load, one command to serve. 336x faster than Python inference. - kossisoroyce/timber
Mar 2026 · github.com · its alternatives →
- 24
Hey HN, Henry and Roman here - we've been building a cross-platform framework for deploying LLMs, VLMs, Embedding Models and TTS models locally on smartphones. Ollama enables deploying LLMs models locally on laptops and edge severs, Cactus enables deploying on phones. Deploying directly on phones facilitates building AI apps and agents capable of phone use without breaking privacy, supports real-time inference with no latency, we have seen personalised RAG pipelines for users and more. Apple and Google actively went into local AI models recently with the launch of Apple Foundation Frameworks…
2025 · github.com · its alternatives →
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Ranked by how close each launch is in meaning, then by votes. Prices were read from each product’s own site when checked and can change. Refine with your own description →