Harmonic Discovery

What it does

Harmonic Discovery uses machine learning and generative chemistry to design medicines with fewer harmful off-target effects and better multi-target activity for complex diseases.

Current paradigm of drug discovery favors designs that target a single biologicalfrom harmonicdiscovery.com

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  Harmonic Analyzer2022 · nickplee.com · ▲122

  Learn how to play your favorite piano songs using ML

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  An open-source implementation of AlphaFold32024 · github.com · ▲314

  Hi HN - we’re the founders of Ligo Biosciences and are excited to share an open-source implementation of AlphaFold3, the frontier model for protein structure prediction. Google DeepMind and their new startup Isomorphic Labs, are expanding into drug discovery. They developed AlphaFold3 as their model to accelerate drug discovery and create demand from big pharma. They already signed Novartis and Eli Lilly for $3 billion - Google’s becoming a pharma company! (https://www.isomorphiclabs.com/articles/isomorphic-labs-kick...) AlphaFold3 is a biomolecular structure prediction…

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  AlphaFold 32024 · blog.google · ▲161

  Predicting the structure & interactions of life’s molecules

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  Tweak your chord progressions for practice or composition2023 · chord-alt.vercel.app · ▲78

  I'm excited to share with HN a new pet project I've been working on to explore how AI can create and explain harmonic chord progressions - Chord Variations. The project uses GPT-4 to generate unique and interesting chord combinations based on user input chord progression. It's akin to having a virtual musical assistant that can help non-musicians and musicians alike explore and create harmonious sound without needing any prior knowledge of music theory. The generated chord suggestions maintain a similar vibe to the user input. Alternative chord progression includes extended chords, chord…

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  Distill2017 · distill.pub · ▲200

  An interactive, visual journal for Machine Learning research

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  Video model that turns script into viral social media videos

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  The browser where Claude Code and Codex work beside you

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  Germany's new sovereign AI model Kolibri▲424

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  AI · May 2026 · pollyreach.ai

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  Needle: We Distilled Gemini Tool Calling into a 26M Model▲776

  Hey HN, Henry here from Cactus. We open-sourced Needle, a 26M parameter function-calling (tool use) model. It runs at 6000 tok/s prefill and 1200 tok/s decode on consumer devices. We were always frustrated by the little effort made towards building agentic models that run on budget phones, so we conducted investigations that led to an observation: agentic experiences are built upon tool calling, and massive models are overkill for it. Tool calling is fundamentally retrieval-and-assembly (match query to tool name, extract argument values, emit JSON), not reasoning. Cross-attention…

  Life & fun · May 2026 · github.com

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  Files.md – Open-source alternative to Obsidian▲730

  🌱 Private, quiet space for thinking. Simple app for .md files. - zakirullin/files.md

  Dev tools · May 2026 · github.com