I made an open-source Rust program for memory-efficient genomics
My cofounder and I run a startup in oncology, where we handle cancer genomics data. It occurred to me that, thanks to a recent complexity theory result, there's a clever way to run bioinformatics algorithms using far less RAM. I built this Rust engine for running whole-genome workloads in under 100MB of RAM. Runtime is a little longer as a result - O(TlogT) instead of O(T). But it should enable whole-genome analytics on consumer-grade hardware.
I made an open-source Rust program for memory-efficient genomics launched on November 13, 2025 with 17 votes, #675 of 9,796 launches that month and more than 90% of that year's launches.
In plain words
This open-source Rust program enables bioinformatics analysis on consumer hardware by running whole-genome workloads in under 100MB of RAM. Built for oncology researchers and genomics developers, it uses a complexity theory approach to reduce memory requirements, trading slightly longer processing times for dramatically lower resource consumption. The tool makes sophisticated genomics analytics accessible without expensive server infrastructure.
written from the facts on this page · September 2026
From the sources
Deterministic, resource-governed per-locus genomics analyses with transactional artifacts, receipts, replay, Arrow, and reproducible sharding. - logannye/rosalind
Does a similar job
all alternatives →
LocalGPT – A local-first AI assistant in Rust with persistent memoryFeb 2026 · github.com · ▲331I built LocalGPT over 4 nights as a Rust reimagining of the OpenClaw assistant pattern (markdown-based persistent memory, autonomous heartbeat tasks, skills system). It compiles to a single ~27MB binary — no Node.js, Docker, or Python required. Key features: - Persistent memory via markdown files (MEMORY, HEARTBEAT, SOUL markdown files) — compatible with OpenClaw's format - Full-text search (SQLite FTS5) + semantic search (local embeddings, no API key needed) - Autonomous heartbeat runner that checks tasks on a configurable interval - CLI + web interface + desktop GUI - Multi-provider:…
I'm making a dynamic language in Rust2022 · github.com · ▲184An implementation of a dynamic programming language in Rust. Includes: Parser/Compiler, REPL, Virtual Machine, Bytecode Disassembler This started out as a learning project to teach myself Rust. It has grown into a decently substantial piece of software and I've learned quite a bit in the process! Some neat things: + A garbage collector that can store dynamically sized types without any double-indirection (i.e. I have my own Box implementation with manual alloc/dealloc) + The smart pointer used to reference GCed data is a thin pointer. The ptr metadata needed for DSTs is stored in…
We made our own inference engine for Apple Silicon2025 · github.com · ▲186We wrote our inference engine on Rust, it is faster than llama cpp in all of the use cases. Your feedback is very welcomed. Written from scratch with idea that you can add support of any kernel and platform.
- AFApache Fory Rust – 10-20x faster serialization than JSON/ProtobufOct 2025 · fory.apache.org · ▲67
Serialization framework with some interesting numbers: 10-20x faster on nested objects than json/protobuf. Technical approach: compile-time codegen (no reflection), compact binary protocol with meta-packing, little-endian layout optimized for modern CPUs. Unique features that other fast serializers don't have: - Cross-language without IDL files (Rust ↔ Python/Java/Go) - Trait object serialization (Box) - Automatic circular reference handling - Schema evolution without coordination Happy to discuss design trade-offs. Benchmarks:…
I wrote a tool in Rust for tracking all allocations in a Linux process2023 · github.com · ▲113allocscope - a memory tracking tool. Contribute to matt-kimball/allocscope development by creating an account on GitHub.
SwimOS Rust – A framework for real-time streaming data applications2024 · github.com · ▲71
More dev tools this month
the category →
open-source IDE for thoughtful software design. Contribute to devdotfast/whiteboard development by creating an account on GitHub.
Dev tools · 27d ago · github.com
Contribute to reladraw/reladraw development by creating an account on GitHub.
Dev tools · 25d ago · github.com
OpenBot▲362Grok Bot alternative: free, local, open-source, multiplayer
Dev tools · 22d ago · openbot.run
Talanoa▲343Hi HN, I’m a fullstack developer, and honestly, I’ve lost count of how many side projects I’ve worked on over the years. But one idea kept coming back to me: a different kind of email client. It first came to me in 2014: “What if we could handle emails more like conversations?” Every year, I’d revisit this concept in my “Build Notes.” Ten years later, no one had built exactly what I had in mind — so I finally decided to do it myself. That’s how Talanoa was born. I wanted something focused on people, not timelines. I was tired of marking messages as unread just to remember to reply later, or…
Dev tools · 20d ago · talanoa.email
CoreSpeed▲332One MCP for everything your agents need: apps, memory, tools
Dev tools · 28d ago · corespeed.io
Source: Show HN post ↗
Launched alongside, November 2025
the whole month →
Guideflow▲1,338Create interactive product demos and step-by-step guides in seconds with Guideflow, the leading AI-powered demo automation tool.
AI · Nov 2025 · guideflow.com
Hardware and software projects by Ali Roberts
Life & fun · Nov 2025 · bitsnpieces.dev
Welltory▲1,028Measure your wellness. Use data to feel great every day.
Work · Nov 2025 · welltory.com
TrustMRR▲833LLM Gateway is a b2b artificial intelligence based in United States, founded in 2025. $259,539/month in verified Stripe revenue. $78,764 MRR. Ahrefs Domain Rating 52/100. growing 55% month-over-month. Track LLM Gateway's verified metrics on TrustMRR.
Growth · Nov 2025 · trustmrr.com
Boing▲782Life & fun · Nov 2025 · boing.greg.technology