Alternatives
Products that do what ESM C, setting a new state of the art for protein language models does
Hey HN! We're releasing ESM C, a series of protein language models that set a new state of the art. By training on metagenomics and fine-tuning on UniRef, we're able to match ESM2 650M with ESM C 300M, and ESM C 6B has incredible unsupervised contact precision performance. These models are meant to be used as base models and representation learning models for protein sequences, and we'll release a preprint describing exact details soon.
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Built a ~9M param LLM from scratch to understand how they actually work. Vanilla transformer, 60K synthetic conversations, ~130 lines of PyTorch. Trains in 5 min on a free Colab T4. The fish thinks the meaning of life is food. Fork it and swap the personality for your own character.
Apr 2026 · github.com
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Hi HN - we’re the founders of Ligo Biosciences and are excited to share an open-source implementation of AlphaFold3, the frontier model for protein structure prediction. Google DeepMind and their new startup Isomorphic Labs, are expanding into drug discovery. They developed AlphaFold3 as their model to accelerate drug discovery and create demand from big pharma. They already signed Novartis and Eli Lilly for $3 billion - Google’s becoming a pharma company! (https://www.isomorphiclabs.com/articles/isomorphic-labs-kick...) AlphaFold3 is a biomolecular structure prediction…
2024 · github.com
- 3ML
We’ve recently open-sourced Model2vec, a method to distill sentence transformers into static embeddings that outperform all previous approaches by a large margin on MTEB. Our new models set a new state-of-the-art for static embeddings. Main features: - Our best model (potion-base-8M) has only 8M parameters, which is ~30mb on disk - Inference is ~500x faster than the distilled base model (bge-base), on a CPU - New models can be distilled in 30 seconds on a CPU without requiring a dataset - just a vocabulary - Numpy-only inference: The packaged can be install the package with minimal…
2024 · github.com
- 4PO
Hi HN, OpenAI recently released a model for automatic speech recognition called Whisper [0]. I decided to reimplement the inference of the model from scratch using C/C++. To achieve this I implemented a minimalistic tensor library in C and ported the high-level architecture of the model in C++. The entire code is less than 8000 lines of code and is contained in just 2 source files without any third-party dependencies. The Github project is here: https://github.com/ggerganov/whisper.cpp With this implementation I can very easily build and run the model - “make…
2022 · github.com
- 5TO
Mar 2026 · github.com
- 6MR
Hey HN! We’ve just open-sourced model2vec-rs, a Rust crate for loading and running Model2Vec static embedding models with zero Python dependency. This allows you to embed text at (very) high throughput; for example, in a Rust-based microservice or CLI tool. This can be used for semantic search, retrieval, RAG, or any other text embedding usecase. Main Features: - Rust-native inference: Load any Model2Vec model from Hugging Face or your local path with StaticModel::from_pretrained(...). - Tiny footprint: The crate itself is only ~1.7 mb, with embedding models between 7 and 30 mb. Performance:…
2025 · github.com
- 7TA
2015 · autoprotocol.org
- 8WT
After working with LLMs for long enough, I found myself wanting a lightweight utility for doing various small tasks to prepare inputs, locate information and create evaluators. This library is two things: a very simple model and utilities that inference it (eg. fuzzy deduplication). The target platform is CPU, and it’s intended to be light, fast and pip installable — a library that lowers the barrier to working with strings semantically. You don’t need to install pytorch to use it, or any deep learning runtimes. How can this be accomplished? The model is simply token embeddings that are…
2024 · github.com
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We show the potential of modern, embedded graph databases in the browser by demonstrating a fully in-browser chatbot that can perform Graph RAG using Kuzu (the graph database we're building) and WebLLM, a popular in-browser inference engine for LLMs. The post retrieves from the graph via a Text-to-Cypher pipeline that translates a user question into a Cypher query, and the LLM uses the retrieved results to synthesize a response. As LLMs get better, and WebGPU and Wasm64 become more widely adopted, we expect to be able to do more and more in the browser in combination with LLMs, so a lot of…
2025 · blog.kuzudb.com
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A simple R package which helps with annotation of single cell experiments such as single cell RNA-seq. With up and down regulated genes per cell cluster, the local LLM guesses the cell type annotation and creates an overall extensive report.
2024 · github.com
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Hi HN, We've just published a lot of original, visual, and intuitive explanations of concepts to introduce people to large language models. It's available for free with no sign-up needed and it includes text articles, some video explanations, and code examples/notebooks as well. And we're available to answer your questions in a dedicated Discord channel. You can find it here: https://llm.university/ Having written https://jalammar.github.io/illustrated-transformer/, I've been thinking about these topics and how best to communicate them for half a…
2023
- 16CA
Hi HN! We’re been working hard on this low-code tool for rapid prompt discovery, robustness testing and LLM evaluation. We’ve just released documentation to help new users learn how to use it and what it can already do. Let us know what you think! :)
2023 · chainforge.ai
- 17KG
Hi HN! My latest side project is knowledge graph that maps the French culinary network using data extracted from restaurant reviews from LeFooding.com. The project uses LLMs to extract structured information from unstructured text. Some technical aspects you may be interested in: - Used structured generation to reliably parse unstructured text into a consistent schema - Tested multiple models (Mistral-7B-v0.3, Llama3.2-3B, gpt4o-mini) for information extraction - Created an interactive visualization using gephi-lite and Retina (WebGL) - Built (with Claude) a simple Flask web app to clean and…
2025 · theophilecantelob.re
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2023 · github.com
- 19FC
Hi HN! I've found this visualization tool immensely helpful over the years for getting an intuition for how an LLM "sees" some piece of text, and with a bit of elbow grease decided to move all compute to client side so I could make it publicly available. I've found it particularly useful for - Understanding exactly how repetition and patterns affect a small LM's ability to predict correctly - Understanding different tokenization patterns and how it affects model output - Getting a general sense of how "hard" different prediction tasks are for GPT-style models Known problems (that I probably…
2023 · perplexity.vercel.app
- 20FG
We developed a new framework that enables flexible control of generated text in language models. By combining several models and/or system prompts in one mathematical formula, it lets you tweak your style and combine model outputs with ease. A handy tool for those working with LLMs, looking for more fine-grained control of stylistic output. More details in our paper: https://arxiv.org/abs/2311.14479. Feedback and potential applications are welcome.
2023 · github.com
- 21LA
G'day, HN! I'm one of the maintainers of `llm`. I've been working alongside a trusty group of contributors to bring this project to life, and we're now at a point where we're ready to share it with the world. Large language models (LLMs) are taking the computing world by storm due to their emergent abilities that allow them to perform a wide variety of tasks, including translation, summarization, code generation, and even some degree of reasoning. However, the ecosystem around LLMs is still in its infancy, and it can be difficult to get started with these models. `llm` is a one-stop shop for…
2023 · github.com
- 22KA
Hi everyone, I'm happy to announce the release of Kalosm! [Kalosm](https://floneum.com/kalosm/) is a framework for embedded AI in rust. ## What is Kalosm? Kalosm provides a simple interface for pre-trained language, audio, and image models models. To make it easy to use with these models in your application, Kalosm includes a set of integrations other systems like your database or documents. ```rust use kalosm::language::*; #[tokio::main] async fn main() { let mut model = Llama::new_chat(); let mut chat = Chat::builder(&mut model) .with_system_prompt("The assistant will…
2024 · floneum.com
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2023 · lama.nbnl.uk
- 24NG
Hi everyone, I started working on nanoeuler after the ban of anthropic's fable because my ambition and dream is to work in the AI field in anthropic. The two interesting reasons that led me to create nanoeuler were (1) interfacing with llm does not mean understanding how they are composed and (2), working on llm with a very low-level layer to understand the correlation between parameters and data and growth of the model and how the GPU works and how some layers can be optimized. So I started working on it with a research aspect by making nanoeuler grow more and more but doing one step after…
Jun 2026 · github.com
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