Life & fun · September 4, 2026
5-Amino 1MQ (Extra)
Beligas 5-Amino 1MQ Extra – Metabolic & NNMT Inhibitor
What it does
Beligas 5-Amino 1MQ Extra is a specialized small-molecule metabolic compound designed to target Nicotinamide N-methyltransferase (NNMT) enzyme activity. By inhibiting NNMT, it promotes intracellular NAD+ and SAM recycling, driving cellular energy metabolism, enhanced fat oxidation, and mitochondrial efficiency without affecting central nervous system stimulants. Engineered for optimal oral absorption and stability, it supports advanced weight management research and energy optimization.
Does the same job
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- IWI wrote a GPU-less billion-vector DB for molecule search (live demo)2025 · cheese-new.deepmedchem.com · ▲9
Input a SMILES string (or pick one molecule from the examples) and it returns up to 100k molecules closest in 3-D shape or electrostatic similarity – from 10+ billion scale databases — typically in under 5-10 s. *Why it might interest HN* * Entire index lives on disk — no GPU at query-time, less than ~10 GB RAM total. * Built from scratch (no FAISS index / Milvus / Pinecone). * Index-build cost: one Nvidia T4 (~ 300USD) for one 5.5B database. * Open to anyone, predict ADMET, export results as CSV/SDF. Full write-up & benchmarks (DUD-E, LIT-PCBA, SVS) in the pre-print:…
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Hi HN, I built Eigendrum, a web tool that solves the 2D wave equation for arbitrary shapes so you can hear what they sound like as drums. How it works: * Solves -∇²u = λu using finite element analysis (Kφ = λMφ) on a triangle mesh. * Validated to <0.1% error against closed-form solutions for circles (Bessel zeros) and rectangles. * Sound model factors in strike location, Rayleigh damping, and mallet width. * Includes Kac drums I & II to demonstrate identical sound spectra from different geometries. * No frameworks, build steps, or dependencies. Repo and tests:…
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Dev tools · 1d ago · opentrailpaper.com
Run Qwen3.8-Flash-Next (125B MoE, 104 GB at 4-bit) on Macs with a fraction of that RAM by streaming experts from SSD. MLX + Swift, Ollama-compatible API. - carloslfu/slotstream
Dev tools · 4d ago · github.com
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AI · 2d ago · github.com
Weedout is a Safari extension that filters out videos YouTube labels as “Made with AI”.
AI · 4d ago · masteranza.github.io
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AI · 4d ago · hnmatchmaker.com
I made OwnTime to balance between competing priorities in my life. The idea is based on two main influences: the concept of "roles" from "The 5 Choices" (2015), and my repeated failure to effectively implement time blocking due to the necessary flexibility in my role. The app allows you to define time budgets, which are not much more than a few mutually exclusive countdown timers. The UX is essentially that of a chess clock for an arbitrary number of players with configurable time. The whole point of the app is to kick you out of the running role/priority when its time is up. One…
Life & fun · 4d ago · owntime.app