GeneGuessr – a daily biology web puzzle
I made a web game inspired by Geoguessr and Wordle, where you get shown a 3D model of a random human protein each day, and you have to triangulate its gene name using similarity clues. My background is in wet lab molecular biology and I intend this game to be engaging mostly to other biologists. But if you're outside the field, I'm interested to know if you can still solve it with browser use LLMs, and if you learned something interesting doing so. Let me know what you think. I made it with Claude over the last 2 months. My coding experience is limited to basic python data analysis and…
GeneGuessr – a daily biology web puzzle launched on December 23, 2025 with 88 votes, #348 of 11,628 launches that month and more than 95% of that year's launches.
In plain words
GeneGuessr is a daily web puzzle game that displays a 3D model of a random human protein and challenges players to identify its gene name using similarity clues. Inspired by Geoguessr and Wordle, it targets biologists primarily but welcomes players from other fields to attempt solving puzzles with browser tools or AI assistance. The game demonstrates what a functional web application can look like when built by someone with limited coding experience, leveraging AI development tools to bridge technical gaps.
written from the facts on this page · September 2026
From the sources
Can you identify the protein from its 3D structure? A daily guessing game where you use clues about domains, pathways, and molecular functions to figure out which gene made the protein.
This is the protein of the day. Can you figure out which gene made it? You will see spoiler bars that cover valuable hints. Tap the spoiler bar to reveal a hint underneath. Look up your favorite gene with the search bar. Submit it as your first guess. It costs 1 hint to remove a spoiler bar. You get +1 hint for each guess. When the hint is too obvious, the bar stays locked. Just try unlocking another one. You get to make 10 guesses before the game ends. Feel free tofrom geneguessr.brinedew.bio
In the maker’s words, at launch
I made a web game inspired by Geoguessr and Wordle, where you get shown a 3D model of a random human protein each day, and you have to triangulate its gene name using similarity clues. My background is in wet lab molecular biology and I intend this game to be engaging mostly to other biologists. But if you're outside…
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