Dev tools · alternatives · 2026
24 alternatives to GeneGuessr – a daily biology web puzzle
I made a web game inspired by Geoguessr and Wordle, where you get shown a 3D model of a random human protein each day, and you have to triangulate its gene name using similarity clues. My background is in wet lab molecular biology and I intend this game to be engaging mostly to other biologists. But if you're outside the field, I'm interested to know if you can still solve it with browser use LLMs, and if you learned something interesting doing so. Let me know what you think. I made it with Claude over the last 2 months. My coding experience is limited to basic python data analysis and…
GeneGuessr is a daily web puzzle game that displays a 3D model of a random human protein and challenges players to identify its gene name using similarity clues. Inspired by Geoguessr and Wordle, it targets biologists… Below are 24 products that do a similar job, ranked by how close each is in meaning and then by launch-day votes.
- 1
I’ve been working on this for about a year through four major rewrites. Godogen is a pipeline that takes a text prompt, designs the architecture, generates 2D/3D assets, writes the GDScript, and tests it visually. The output is a complete, playable Godot 4 project. Getting LLMs to reliably generate functional games required solving three specific engineering bottlenecks: 1. The Training Data Scarcity: LLMs barely know GDScript. It has ~850 classes and a Python-like syntax that will happily let a model hallucinate Python idioms that fail to compile. To fix this, I built a custom…
Mar 2026 · github.com · its alternatives →
- 2
I started this trying to understand two things: why my Asian friends turn red after drinking, and why several friends all seemed to have migraine clusters. I was reading medical papers and textbooks, but kept getting lost jumping between topics. I thought: what if I could just Cmd+Click through this like code? What if "ALDH2 gene" was actually clickable, and took me to the variant, the phenotype, the population frequencies? So I started modeling human biology in Rust with my Ralph agent (Claude in a loop, ty ghuntley). Turns out the type system is perfect for this. Every biological entity is…
2025 · github.com · its alternatives →
- 3
GitGuessr▲98I built this game as a playful way to train code reading skills. You're dropped into a random location in a real GitHub repo where some lines code are hidden. The goal is to pick up clues from the surrounding code and fill in the missing lines as quickly as possible. It currently has curated game content for Python, TypeScript, JavaScript (by most metrics the top 3 languages on GitHub). I had the idea when it dawned on me that reviewing and understanding code spat out by an LLM is a key skill for the AI era. (I sincerely hope you're critically reviewing what your favorite LLM is serving…
Feb 2026 · gitguessr.com · its alternatives →
- 4WA
Online DNA and Protein Sequence Tools, Alignments, Reverse complement, Translation, Sequence annotation, design Primers
2017 · genewarrior.com · its alternatives →
- 5
Languessr is a language game which shows you summaries of Wikipedia articles and challenges your ability to recognize languages.
2023 · languessr.xiupos.net · its alternatives →
- 6
I'm a journalist and product developer by day, and a curious generalist who loves making things whenever I find time. I've always loved building little web apps, even with my limited coding skills. As a student and early in my career, I had a lot of time, so it didn't matter. In recent years however, with life being busy as it is, most of my ideas stayed at the back of my mind. There simply wasn't enough time to compensate for my limited skills. Until I started working with Cursor, that is. All of a sudden, the time needed to turn an idea into a working prototype is once again within what…
2025 · dataguessr.com · its alternatives →
- 7
Personalized Genomics and Proteomics. Main diet: Ensembl, side dishes: SNPs - tariqdaouda/pyGeno
2016 · github.com · its alternatives →
- 8GA
Hi everyone! Graphs is the intersection of data visualization and the daily web puzzle genre (Wordle, NYT Mini Crossword, Connections, etc.). Every day, you are given a nameless graph and 5 options to select the right dataset it is representing. Upon winning, you can access the underlying dataset and other info + maintain a streak and stats. It's super simple - check out today's chart and you should be able to get the gist quickly. My email + twitter account (@graphsgame) is on the page, would love a feedback or a follow. Don't hesitate to reach out!
2024 · graphs.world · its alternatives →
- 9
I initially released this as just an IOS app. Since then it has been growing steadily but a lot of people have emailed asking for a web / android version. It took me nearly 2 months to build a version for the web. The nice thing about using Convex as my backend is that all the data is always synced between the app and web. I do not have to setup any syncing logic. The moment you change something in the app, it will reflect on the web version in realtime. I know there are loads of these kind of tools online but it's starting to feel like mine is actually starting to differentiate itself…
2025 · three-cells.com · its alternatives →
- 10
I’m a game show nerd who wanted to build a game, despite not being a developer. Using ChatGPT, I created Feudle – a blend of Family Feud and Wordle. Each day, there’s a survey question, and players try to guess the most popular responses—but the twist is that today’s answers come from real players who played yesterday. After playing, you can vote on or submit new questions, shaping future Feudles. If I were to start again, I’d explore newer AI-assisted coding tools like Cursor, but overall, this was a great learning experience. Hopefully, this inspires others to experiment with AI tools to…
2025 · feudlegame.com · its alternatives →
- 11
Hi HN — I’ve been working on Gene, a general-purpose, homoiconic language with a Lisp-like surface syntax, but with a core data model that’s intentionally not just “lists all the way down”. What’s unique: the Gene data type Gene’s central idea is a single unified structure that always carries (1) a type, (2) key/value properties, and (3) positional children: (type ^prop1 value1 ^prop2 value2 child1 child2 ...) The key point is that the type, each property name, each property value, and each child can themselves be any Gene data. Everything composes uniformly. In practice this is…
Jan 2026 · github.com · its alternatives →
- 12SA
Hi HN, I was late to wordle, so I am also late to making my own version. In Spindle, you rotate words on a grid with the aim of assembling the day’s target word. I enjoy it, so I thought some of you might enjoy it too. From a tech perspective, it’s a very simple Laravel / Livewire app. My happy place in recent years has been Typescript and SvelteKit, so this was a bit of an adjustment, but it allowed me to take advantage of an existing shared hosting server meaning no additional financial outlay. Happy to report a positive experience with PHP and this framework, although I do miss…
2023 · playspindle.com · its alternatives →
- 13
We’ve built Synergetica, an open-source desktop app for end-to-end genetic circuit design. It supports node-based or code-based editing, interactive simulations, and automated DNA sequence generation. You can find the repo and docs here: - GitHub: https://github.com/khokao/synergetica - Docs: https://khokao.github.io/synergetica/
2025 · github.com · its alternatives →
- 14WS
Some months ago @andrewrn tried to create a Wordle-style site for order-of-magnitude thinking. This was a wonderful idea, but the actual site was somewhat over-engineered and confusing. (https://news.ycombinator.com/item?id=43632278) In the past week, I looked at this idea again and built a very simple site which gives you a new Fermi estimation question every day: How many new cars were sold in the US in 2024?; How many humans have ever lived (including those currently alive)?; How many chickens are slaughtered for meat every year? To win, you need a guess within ±20% of the…
2025 · fermiquestions.org · its alternatives →
- 15IB
My friend and I made a fully featured gaming geoguessr - complete with 360 degree panoramas, movement, leaderboards, and multiplayer. We had made a Fortnite geoguessr a while back, and although this was well received, our goal always was to bring the worlds of all games to the browser. A much harder task considering the scale and scope of many open world games. We had to make a bunch of tools to be able to achieve this. World of Warcraft alone took us roughly 3,000,000 images to do (and will likely need another 1,000,000 for Dragonflight once it releases). We are finally at a point where we…
2022 · lostgamer.io · its alternatives →
- 16
at a pub in london, 2 weeks ago - I asked myself, if you spawned agents into a world with blank neural networks and zero knowledge of human existence — no language, no economy, no social templates — what would they evolve on their own? would they develop language? would they reproduce? would they evolve as energy dependent systems? what would they even talk about? so i decided to make myself a god, and built WERLD - an open-ended artificial life sim, where the agent's evolve their own neural architecture. Werld drops 30 agents onto a graph with NEAT neural networks that evolve their own…
Feb 2026 · github.com · its alternatives →
- 17IM
http://codewords.io/ I've been trying to get permission to run a game of it from the publisher and designer (CGE & Vlaada Chvátil) but I haven't heard back. I've found demonstrating that there's interest in what you're doing is the best way to get ahold of people. So.. Anyone interested in trying a massive game of Codenames over Twitch? Not quite "For Science!" more "For Engineering!" Which, let's be honest here, has a much better ring to it. If you'd like to know more, I put up an FAQ up here: http://codewords.io/faq/ If you'd like to sign up to help,…
2017 · its alternatives →
- 18MF
Wrote a program in FreeBASIC to try and find out how Genetic Algorithms work. It's a quick hack that I wrote to try some theories with because the Wikipedia Article on GAs reads like greek to me. So I built it from the general principles i knew at the time. The "genome" per individual is an array of 9000 integers but I used only monochrome pictures with either black or white; An individual also has a fitness score. There are 1000 individuals in the population and only two are selected to reproduce. So that makes 9 million (yes, MEELION as El Reg would write) data points and the scoring…
2015 · its alternatives →
- 19
Hello HN! I'm a big fan of Wordle and I originally got this idea from seeing people gripe about Wordle suddenly being "harder" than usual. Wondering if this was true, I set out to snoop around the NYT's publicly available data, which gave me some pretty cool insights. I've put some of them on this simple site made with React and Claude. There's a grand total of 7 visualizations, with some fun little touches here and there. My favorite is probably "Clairvoyant Guesses," which shows some (to put it nicely) suspicious day-to-day guessing patterns. There's also a fun little easter egg when you…
2025 · wordlecharts.crtez.dev · its alternatives →
- 20LA
I used to play the Wikipedia Game in high school and had an idea for applying the same mechanic of clicking from concept to concept to LLMs. Will post another version that runs with an LLM entirely in the browser soon, but for now, please enjoy as long as my credits last... Warning: the LLM does not always cooperate
Jan 2026 · llmgame.ai · its alternatives →
- 21OS
Everyone saw the AlphaEvolve hype. I got obsessed with how it might work under the hood and decided to just build it myself. My setup uses GPT-4.1 to mutate matrix multiplication code, guided by a bunch of hand-crafted mutation strategies (loop reordering, tiling, Strassen, etc.). Each candidate is evaluated on both speed and accuracy. Then I apply Pareto selection with crowding distance to evolve better ones over generations. I ran into all the usual LLM reward hacks-returning the input, calling np.dot, etc. So I forced primitive-only implementations and tightly constrained the mutation…
2025 · its alternatives →
- 22
When: recombinant design pattern for state machines with a temporal model - voodooattack/when-ts
2018 · github.com · its alternatives →
- 23
DLES.gg▲14It's crazy, the world of Wordle style games is totally booming. After I made my own daily game, I started to be interested in the area, I started to collect games I found interesting and put together a directory. I shared it here and there and add a 'submit a game' button, I'm having about 3-5 new games submitted every single week, similarly in the r/wordgames there's a new game concept launched multiple times a week. This sector is totally booming. The cost of developing a game is close to 0 and all the non-coder people who had an idea are now shipping daily games. It's wild and…
2025 · dles.gg · its alternatives →
- 24
I’ve been working on a browser-based evolutionary simulation as a personal experiment. Organisms adapt to environmental pressure over time, and there are no explicit goals or scoring, the system is open-ended and runs continuously. I built this mainly to challenge myself and to explore how to surface simulation behavior and statistics in a way that stays readable rather than overwhelming. As a side effect, it’s also something my kids enjoys watching run. Curious what resonates and what doesn’t, and happy to answer questions about the design or tradeoffs.
Jan 2026 · soupof.life · its alternatives →
Also compare
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- Modeling the human body in Rust so I can cmd+click through it alternatives
- GitGuessr alternatives
- Web app for DNA sequence manipulation and PCR Primer design alternatives
- Languessr – a game where you guess the language of a Wikipedia article alternatives
- DataGuessr – a daily quiz that teaches global statistics through play alternatives
Ranked by how close each launch is in meaning, then by votes. Prices were read from each product’s own site when checked and can change. Refine with your own description →